(A) Asymmetric cell division in Caulobacter crescentus is driven by a single-domain response regulator (DivK~P, shaded gray within cell cartoons) that has been inversely correlated with the activity of a cell-cycle kinase (CckA) that in turn activates the CtrA transcription factor regulating over 100 developmental genes.

(B) The kinase DivJ phosphorylates DivK in the stalked compartment, while PleC dephosphorylates DivK in the swarmer compartment. The pseudokinase DivL forms a complex with DivK~P and couples these two signaling pathways.

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