FIGURE 1: The enzyme PGP/Pho13 eliminates glycolytic side products and allows parallel action of glycolysis and the pentose phosphate pathway.

Side activities of glycolytic enzymes are shown in blue; new metabolite repair activities in green and inhibitory interferences discovered or characterized in the paper of Collard and colleagues in red. 6PGDH, 6-P-gluconate dehydrogenase; PGK, phosphoglycerate kinase; 6PG-lactone, 6-P-gluconolactone; Ru5P, ribulose-5-P; BP, bisphospho; PFK-2, phosphofructokinase-2. Modified from [2].

2. Collard F, Baldin F, Gerin I, Bolsee J, Noel G, Graff J, Veiga-da-Cunha M, Stroobant V, Vertommen D, Houddane A, Rider MH, Linster CL, Van Schaftingen E, Bommer GT (2016). A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast. Nature chemical biology 12(601-607).

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