FIGURE 1: Major yeast and mammalian SL metabolic pathways. Both overlapping parts (white square) and yeast- (green square) and mammalian (blue square)-specific processes are indicated as well as the targets of commonly used inhibitors of SL biosynthesis. Adapted from [87].

87. Rego A, Trindade D, Chaves SR, Manon S, Costa V, Sousa MJ, Corte-Real M (2013). The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids. FEMS yeast research 14(1): 160-178. http://dx.doi.org/10.1111/1567-1364.12096