FIGURE 2: Schematic depiction of reactions involved in generation and use of Acetyl CoA.

Genes induced in response to alkaline pH stress are in red background whereas those repressed are in green background. Expression profiles have been collected from published transcriptomic data [14, 18, 22, 56, 68, 97]. Genes whose expression has been found to be dependent of Snf1 according to [56] are framed.

14. Causton HC, Ren, B, Koh, SS, Harbison, CT, Kanin, E, Jennings, EG, Lee, TI, True, HL, Lander, ES, and Young, RA (2001). Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell 12(2): 323-337.

18. Viladevall L, Serrano, R, Ruiz, A, Domenech, G, Giraldo, J, Barcelo, A, and Arino, J (2004). Characterization of the calcium-mediated response to alkaline stress in Saccharomyces cerevisiae. J Biol Chem 279(42): 43614-43624.

22. Serrano R, Martin, H, Casamayor, A, and Arino, J (2006). Signaling alkaline pH stress in the yeast Saccharomyces cerevisiae through the Wsc1 cell surface sensor and the Slt2 MAPK pathway. J Biol Chem 281(52): 39785-39795.

56. Casamayor A, Serrano R, Platara M, Casado C, Ruiz A, and Arino J (2012). The role of the Snf1 kinase in the adaptive response of Saccharomyces cerevisiae to alkaline pH stress. Biochem J 444(1): 39-49.

68. Casado C, Gonzalez A, Platara M, Ruiz A, and Arino J (2011). The role of the protein kinase A pathway in the response to alkaline pH stress in yeast. Biochem J 438(3): 523-533.

97. Lamb TM, Xu, W, Diamond, A, and Mitchell, AP (2001). Alkaline response genes of Saccharomyces cerevisiae and their relationship to the RIM101 pathway. J Biol Chem 276(3): 1850-1856.

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