FIGURE 3: Modulation of heme synthesis dramatically alters the ART potency on nonfermentable media.

(A) HEM2-KD strain is much more sensitive to both ART and DHA on YPGE medium.

(B) ALA increases the resistance of HEM2&3 overexpression (HEM2&3 OE) strain to ART in nonfermentable media. Dropout medium SGE-Ura-Trp was used here. The grey bar represents HEM2&3 OE strain and white bar is the control strain with an empty vector (**, P < 0.01).

(C) While more sensitive to ARTs, HEM2-KD yeast is slightly more resistant to paraquat (PQ), a mitochondria ROS generator.

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