FIGURE 3: Increased mitochondrial coupled respiration imparted by reduced TORC1 signaling extends lifespan in isc1Δ cells.

S. cerevisiae BY4741, isc1Δ, tor1Δ and isc1Δtor1Δ cells were grown in SC-medium to the PDS phase, treated with 10 µM 2,4-dinitrophenol (DNP; ■) or vehicle (DMSO; ○) and kept in the medium at 26oC. The viability was determined by stand-ard dilution plate counts and expressed as the percentage of the colony-forming units at time T in relation to T0. Values are mean ± SD of at least three independent experiments.

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