FIGURE 4: Treatment with a cathepsin inhibitor or monensin reduces LeuLeu-OMe-induced cell death.

(A) Cells were treated with 10 µM Z-Phe-Ala or 30 µM LeuLeu-OMe, alone or in combination.

(B) Cells pre-treated with 100 nM monensin for 30 min was then cultivated in the presence or absence of 30 µM LeuLeu-OMe. While monensin treatment alone had no observable effects on parasite growth (compared to control), monensin treatment significantly reduced LeuLeu-OMe-induced cytotoxicity. Results were presented as mean ± SD from 3 independent experiments. p value for the samples treated with LeuLeu-OMe only or LeuLeu-OMe + monensin at 6 h time point is indicated next to the bracket.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.