FIGURE 4: Phylogenetic tree of drug metabolite transporter 2 (DMT2).

Plasmodium berghei DMT2 was shown to be essential for blood-stage development in vivo. This is a maximum likelihood tree of all homologues found in chromalveolate species and the red alga Cyanidioschyzon merolae using the Giardia lamblia homologue as an outgroup. Nodes with support values <50 are left unresolved. Apicomplexan DMT2 sequences, including the different paralogous sequences, form a distinct and well-supported clade, while the red algal distant homologue and the majority of other chromalveolates sequences sit unresolved at the base of this clade.