FIGURE 7: Sit4p and Sch9p integrate nutrient and stress signaling from TORC1 with ceramide signals to regulate mitochondrial function and CLS in yeast. Cells lacking Isc1p present increased TORC1-Sch9p activity, ultimately leading to mitochondrial dysfunction, decreased oxidative stress resistance and shortened CLS. Apart from sensing signals from TORC1, the ceramide activated protein phosphatase Sit4p and the AGC protein kinase Sch9p also integrate ceramide signaling derived from Isc1p to regulate mitochondrial function, oxidative stress re-sistance and chronological lifespan in yeast.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.