FIGURE 1: Hypothesis model for viral protein mediated chromatin remodeling. The ground state chromatin structure is mediated by H4 tail binding to the acidic patch. Alteration of the chromatin state can be achieved by competition of viral proteins with H4 tail for binding to the acidic patch leading to a viral replication-permissive chromatin structure. Abbreviations: H1, histone H1. H4, histone H4. See text for details.