Back to article: Integrins in disguise - mechanosensors in Saccharomyces cerevisiae as functional integrin analogues

FIGURE 2: Integrin-like proteins in fungi share some of the overall structure and motifs with mammalian integrins. Schematic representation of integrin-like INT1 from Candida albicans and Pneumocystis carinii. Indicated are the approximate locations of some motifs – RGD (the integrin binding site), MIDAS (the metal ion-dependent adhesion site), Y (the conserved tyrosine-residue in the C-terminal part), and hatched marking (the transmembrane domain). A prototypical human integrin subunit is shown at the bottom. This figure is from [70] and is published with permission from John Wiley and Sons. Copyright © 2008, American Society for Microbiology.

70. Kottom TJ, Kennedy CC, Limper AH (2008). Pneumocystis PCINT1, a molecule with integrin-like features that mediates organism adhesion to fibronectin. Mol Microbiol 67(4): 747-761. doi: 10.1111/j.1365-2958.2007.06093.x

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