Back to article: Integrins in disguise - mechanosensors in Saccharomyces cerevisiae as functional integrin analogues

FIGURE 5: Sequence and functional analogy between human talin and yeast Sla1 and Sla2. (A) Yeast Sla1 and Sla2 are homologous to the N-terminal and C-terminal parts of human talin, respectively. (B) A hypothetical model where Sla1 and Sla2 bind and act in analogy to human talin in connecting the mechanosensors to the actin cytoskeleton. Left, human and integrin-talin; right, yeast and mechanosensor-Sla1/Sla2.

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