Back to article: Integrins in disguise - mechanosensors in Saccharomyces cerevisiae as functional integrin analogues


FIGURE 6: Hypothetical model for how changes in the cell wall are sensed by mechanosensors and transmitted to RAS and lead to filamentous growth. Starvation induces changes in the cell wall organisation, and this leads to changes in wall elasticity that are sensed by the mechanosensors. The mechanosensors act as inhibitors of Ras1/2 and/or adenylate cyclase (AC) under normal growth conditions. Starvation relieves this inhibition resulting in increased levels of cAMP and increased PKA activity, which triggers filamentous growth.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.

Close