Back to article: Metabolic reprogramming of Salmonella infected macrophages and its modulation by iron availability and the mTOR pathway

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FIGURE 6: Effect of Salmonella infection, iron perturbation and mTOR inhibition on iron homeostasis in RAW264.7 cells. Protein levels of transferrin receptor (TfR) and ferritin were determined in control and Salmonella infected RAW264.7 cells after 24 hours of infection and either pretreatment with FeCl3/hepcidin or DFP and/or rapamycin for 6 or 1 hours respectively. Representative blots (A) and densitometric quantification of results relative to beta-actin expression (B) are shown. Graphs show means ± SEM. One-way ANOVA with Tukey's multiple comparison correction was performed. Exact p-values (< 0.05) are indicated in the graphs.

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