Back to article: DNA polymerase III protein, HolC, helps resolve replication/transcription conflicts

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FIGURE 2. (A) Head-on collisions between the replication fork and transcription complexes. Because the DnaB fork helicase (green) translocates on the lagging strand template, head-on collisions with RNAP (red) blocks fork progression. (B) Codirectional collisions. DnaB fork helicase can proceed unimpeded, but fork unwinding can stabilize extensive R-loops (RNA/DNA hybrids) behind RNAP. Copyright © American Society for Microbiology, mBio12, 2021, e00184-21 doi: 10.1128/mBio.00184-21

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