Back to article: Host-bacteria metabolic crosstalk drives S. aureus biofilm

FIGURE 1: Summary of the host-pathogen metabolic crosstalk that drives S. aureus biofilms. S. aureus glycolysis induces mitochondrial oxidant stress in host immune cells, leading to increased Irg1 expression and itaconate production. Itaconate inhibits S. aureus glycolysis and promotes the synthesis of extracellular polysaccharides used in biofilms. Created with Biorender.

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