Back to article: Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability

FIGURE 3. Deletion of NSR1 and deletion of the RGG domain of Nsr1 reduces G4-induced recombination in Top1 mutant strains. A.-E. Recombination rates of NSR1, nsr1Δ, and nsr1ΔRGG strains expressing indicated Top1 alleles. Rates are considered statistically significantly different if their 95% confidence intervals (shown as error bars) do not overlap [74].

74. Spell RM, Jinks-Robertson S (2004). Determination of mitotic recombination rates by fluctuation analysis in Saccharomyces cerevisiae. Methods Mol Biol 262: 3-12. 10.1385/1-59259-761-0:003

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