Back to article: Flagellated bacterial porter for in situ tumor vaccine

FIGURE 1: Systemic immune responses via the transport antigens to tumor periphery by Antigen-capture bacteria. The tumor antigen is released by radiotherapy. AC-Bacteria captures the released tumor antigen through electrostatic interaction, and then transports the tumor antigen to the tumor periphery through its own motion characteristics. The antigen is taken up by the functional DCs. The DCs then homed to the lymph nodes to present antigens and activate CD4+ and CD8+ T cells. T cells migrate to the tumor site through the vasculature and attack the tumor by secreting cytokines, etc. IFNγ, interferon-γ; TNFα, tumor necrosis factor α; GzmB, granzyme B; MHC, major histocompatibility factors; TCR, T cell receptor; TLRs, toll-like receptors.

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