Back to article: Infinity war: Trichomonas vaginalis and interactions with host immune response

FIGURE 1: T. vaginalis and the interaction with host immune cells. T. vaginalis stimulates vaginal, ectocervical, and endocervical epithelial cells to release IL-6, MCP-1 and IL-8 (1), resulting in the migration of mast cells and neutrophils to the site of infection (2). There, neutrophils in contact with trichomonads release IL-8 and ROS (3), which activate caspase-3 and decrease Mcl-1, an anti-apoptotic protein (4). Macrophages in contact with neutrophils killed by parasite-induced apoptosis decrease IL-6 and TNF-α and increase IL-10 (5). The interaction between macrophages and T. vaginalis can lead to their apoptosis by caspase-3 activation and downregulation of Bcl-xL (6) or can result in the release of TNF-α, IL-6, and IL-1β (7). Finally, monocytes can kill the protozoan through extracellular traps, while neutrophils use a mechanism known as trogocytosis (8).

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.