Back to article: A chemical genetic screen reveals a role for proteostasis in capsule and biofilm formation by Cryptococcus neoformans

FIGURE 5: The ubiquitin/proteasome-associated mutants identified in the lithium screen have defects in proteins implicated in several stages of the ubiquitin/proteasome system. The strains defective in proteins belonging to a specific functional category of the ubiquitin/proteasome system (for example E1, or DUB) are color-coded and indicated based on their strain designation at the Fungal Genetics Stock Center (, see Table 1). Strains in bold are those that were found to be defective in capsule formation (see Figure 6). Ub, ubiquitin; Nedd8, neural precursor cell expressed, developmentally down-regulated 8; SUMO, small ubiquitin-related modifier; URM1, ubiquitin-related modifier 1; E1, ubiquitin-activating enzyme; E2, ubiquitin-conjugating enzyme; E3, ubiquitin ligase; DUB, deubiquitinating enzyme.

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