Back to article: A chemical genetic screen reveals a role for proteostasis in capsule and biofilm formation by Cryptococcus neoformans

TABLE 1. Ubiquitin/proteasome-associated mutants with altered growth in presence of lithium.

aCNKO, Cryptococcus neoformans knockout, bProteins in bold were previously shown to be PKA-regulated [1], cPredicted functions are based on data retrieved from FungiDB, dRelative (rel.) lithium chloride (LiCl) growth is expressed as normalized fold change of mutant growth in YPD medium supplemented with 100 mM LiCl compared to growth in YPD medium alone. A value > 1 indicates that a mutant was more tolerant to LiCl compared to the mean of the remaining mutants of an individual 96-well plate, while a value < 1 indicates hypersensitivity towards LiCl.

33. Geddes JM, Caza M, Croll D, Stoynov N, Foster LJ, Kronstad JW (2016). Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation. MBio 7(1): e01862-01815.


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