Back to article: Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae

FIGURE 2: Translation initiation is inhibited by farnesol in a Gcn2p-independent manner in C. albicans and S. cerevisiae. Figure shows polysome analyses assessing the effect of farnesol on translation initiation in CAI4 (A) and gcn2∆ (B) strains of C. albicans, and the Σ1278b strain of S. cerevisiae (C). Strains were grown in YPD and various concentrations of farnesol were added as indicated for 15 min prior to extract preparation. Extracts were sedimented on 15-50% sucrose gradients and the absorbance at 254 nm was continuously measured. The position of 40S, 60S and 80S peaks are labelled and the direction of sedimentation is noted.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.