Back to article: Insights from the redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

Figure 1: Previously proposed and the redefined structures of H. pylori LPS from strain 26695. A) Previously in H. pylori strain 26695, the LPS O-antigen domain was proposed to contain the Lewis antigen only, the LPS core-oligosaccharide domain was divided into an inner core and outer core. The inner core is a hexa-saccharide comprised of Glc-Gal-DD-Hep-LD-Hep-LD-Hep-KDO, the outer core is comprised of the Trio, the heptan and glucan. B) Based on our recent study, the LPS structure in H. pylori strain 26695 is redefined: the O-antigen encom-passes more than the Lewis antigen, but also the previously defined outer core structure (the Trio, the glucan and the heptan), whereas the core-oligosaccharide only contains the short hexa-saccharide which was previously assigned as the inner core. Figure reproduced from Li et al. 2017 (doi: 10.1371/journal.ppat.1006280) under the Creative Commons CC BY 4.0 license.

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