Back to article: Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β

FIGURE 6: LRV1 induces the expression of inflammasome-independent NLRs: NLRC2 and NLRC5. (A-B) BMDMs from C57BL/6 mice were infected with LgyLRV1+ or LgyLRV1- parasites or stimulated with a synthetic TLR3 ligand, poly(I:C). After 6 hours, mRNA was quantified by qRT-PCR for NLRC1 and NLRC2 (A) or for NLRC5, NLRX1 and NLRC3 (B). The bar graphs are representative of at least 3 independent experiments, using 2 technical and 2 biological replicates, and showed as mean ± SEM. Non-parametric Student’s t-test was performed. *p < 0.05, **p < 0.01, ***p < 0.001. A cut off value of 2-fold was shown as a dotted line.

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