Back to article: Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β

FIGURE 7: NLRC2 reduces LRV-mediated pathogenesis. (A-D) Mice were infected with LgyLRV1+ or LgyLRV1- parasites in their hind footpad. Weekly lesional swelling in infected NLRC2-/- (A) and NLRC5-/- (C) was monitored as a proxy for disease progres-sion. At the peak of infection (4 weeks), parasite burden in infected NLRC2-/- (B) and NLRC5-/- (D) mice was measured by in vivo luminescence, by injecting mice intra-peritoneally with 15mg/kg luciferin. The representative graph is shown from at least three independent experiments, using two biological replicates in duplicates, and showed as mean ± SEM. Significance was calculated by Student’s t-test (bar graphs) or one-way Anova (disease score), ns: non-significant.

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