Back to article: Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin

FIGURE 3: Spartin requires pyruvate dehydrogenase (PDH) complex activity for cell death protection in aging. (A, C, E) Survival during chronological aging of WT, Dpda1, Dptc6 or Dpkp1 cells expressing dSp or cells harboring the corresponding ev. Data represent mean ± SEM of four independent experiments. CFU, colony-forming units. (B, D, F) Quantification of oxidative stress levels (conversion of DHE to Eth) quantified by flow cytometry.

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