Back to article: The interplay between transcription and mRNA degradation in Saccharomyces cerevisiae


FIGURE 2: Default pathway of mRNA degradation in S. cerevisiae. Almost all mRNAs undergo decay by the deadenylation-dependent pathway. Thereby, the poly(A) tail is gradually and progressively shortened by the deadenylase activity of the Ccr4/Pop2/Not complex. Following deadenylation, the mRNA can be degraded by one of two mechanisms. The major mechanism involves decapping by Dcp1p/2p, following a 5’→3’ decay by Xrn1p. The minor mechanism includes a 3’→5’ decay by the cytoplasmic exosome and Ski7p. AUG and UAA are indicating the beginning and end of the ORF carried by the message. Only relevant decay components are shown by annotated symbols. Proteins which remain associated to translating/degrading mRNAs during different stages of decay are not shown.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.

Close