Back to article: The neuroprotective steroid progesterone promotes mitochondrial uncoupling, reduces cytosolic calcium and augments stress resistance in yeast cells

FIGURE 3: Cellular Ca2+ homeostasis is modulated by progesterone treatment in yeast. Cells were treated with progesterone (10 µg/ml) and challenged with high doses of Ca2+ (150 mM). Intake of Ca2+ as well as Ca2+-clearance in the cytosol to its basal level were measured in wild type (A,B), a DAP1-deletion strain (C,D), as well as in a rho0 strain, incapable of mitochondrial respiration (E,F). Data are shown as mean values of at least three replicates including the standard error of the mean. Statistical analysis was conducted using non-paired Student’s t-test. * = p<0.05; ** = p<0.01; *** = p<0.001; n.s. = non-significant. Emax = global maximum of the respective ethanol-treated control; rLU = relative luminiscence units, Prog = progesterone, ctrl = control.

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