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FIGURE 2: Possible mechanisms of PmtR-PSM interaction.

(1) depicts the canonical mechanism of PSM (red) interaction with the ligand binding pocket, which is located in the distal parts of the interacting PmtR monomers (blue) in the PmtR dimer;

(2) depicts an alternative mechanism, in which PSMs displace the PmtR dimer by intercalating between the DNA and the DNA-binding domain of PmtR.

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