Fluorescent microphotography of a wild type yeast diploid strain and of several deletants of genes involved in the bridge-induced translocation regulatory pathway. The cells were stained with FUN-1 dye (6uM) and visualized with fluorescein and rhodamin filters. Inactive/dead cells appear as yellow while metabolically active/alive cells show red intravacuolar structures. Image by Valentina Tosato (International Center for Genetic Engineering and Biotechnology, Trieste, Italy); modified by MIC. The cover is published under the Creative Commons Attribution (CC BY) license.