TABLE 8. Studies investigating the effects of folate on depressive-like behavior.

5-HT: 5-Hydroxytryptamine; BDNF: Brain-Derived Neurotrophic Factor; CUMS: Chronic Unpredictable Mild Stress; ELS: Early-Life Stres; FST: Forced-Swim Test; GluR1: Glutamate Receptor 1; HDL: High-Density Lipoprotein; MK-801: Non-Competitive NMDA Receptor Antagonist; OFT: Open Field Test; PCPA: Para-Chlorophenylalanine; TST: Tail Suspension Test; WAY100635: 5-HT₁A Receptor Antagonist And Full D₄ Receptor Agonist.

213. Paternain L, Martisova E, Campión J, Martínez JA, Ramírez MJ, and Milagro FI (2016). Methyl donor supplementation in rats reverses the deleterious effect of maternal separation on depression-like behaviour. Behav Brain Res 299: 51–58. doi: 10.1016/j.bbr.2015.11.031
226. Brocardo PS, Budni J, Kaster MP, Santos ARS, and Rodrigues ALS (2008). Folic acid administration produces an antidepressant-like effect in mice: Evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology 54(2): 464–473. doi: 10.1016/j.neuropharm.2007.10.016
227. Gao L, Liu X, Yu L, Wu J, Xu M, and Liu Y (2017). Folic acid exerts antidepressant effects by upregulating brain-derived neurotrophic factor and glutamate receptor 1 expression in brain. Neuroreport 28(16): 1078–1084. doi: 10.1097/WNR.0000000000000887
228. Molina-Hernández M, Téllez-Alcántara NP, Olivera-López JI, and Jaramillo MT (2011). The folic acid combined with 17-β estradiol produces antidepressant-like actions in ovariectomized rats forced to swim. Prog Neuro-Psychopharmacology Biol Psychiatry 35(1): 60–66. doi: 10.1016/j.pnpbp.2010.08.022
232. Brocardo PS, Budni J, Lobato KR, Santos ARS, and Rodrigues ALS (2009). Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test. Behav Brain Res 200(1): 122–127. doi: 10.1016/j.bbr.2009.01.004
234. McCoy CR, Rana S, Stringfellow SA, Day JJ, Wyss JM, Clinton SM, and Kerman IA (2016). Neonatal maternal separation stress elicits lasting DNA methylation changes in the hippocampus of stress-reactive Wistar Kyoto rats. Eur J Neurosci 44(10): 2829–2845. doi: 10.1111/ejn.13404