Targeting GATA transcription factors – a novel strategy for anti-aging interventions?

May 6, 2019

This article comments on work published by Carmona-Gutierrez et al. (Nat Commun., 2019), which identified a natural compound, 4,4'-dimethoxychalcone, inducing autophagy and prolonging lifespan in different organisms through a mechanism that involves GATA transcription factors.

Metabolites in aging and autophagy

April 7, 2014

This article analyzes the implications of specific metabolites in aging and autophagy with special emphasis on polyamine metabolism.