Cryptococcus flips its lid – membrane phospholipid asymmetry modulates antifungal drug resistance and virulence

August 1, 2016

This article comments on work published by Huang et al. (MBio, 2016), which reported that in the pathogenic fungus Cryptococcus neoformans loss of lipid flippase activity sensitized cryptococcal cells to multiple classes of antifungal drugs and abolished fungal virulence in murine models.