Functional link between mitochondria and Rnr3, the minor catalytic subunit of yeast ribonucleotide reductase

May 20, 2019

This article shows that the carbon source affects the abundance of ribonucleotide reductase (RNR) subunits in yeast, with a novel Mec1 signaling axis regulating Rnr3 independently of known DNA damage response pathways, and reveals Rnr3's unexpected role in mitochondrial function.