Metabolic reprogramming of Salmonella infected macrophages and its modulation by iron availability and the mTOR pathway
November 14, 2019
This article shows that iron plays a critical role in both the immune response and metabolic reprogramming of macrophages during infection, influencing the TCA cycle and mTOR pathway, with implications for the growth of intracellular bacteria like Salmonella.
Trehalose-6-phosphate promotes fermentation and glucose repression in Saccharomyces cerevisiae
October 1, 2018
This study examined the capability of trehalose-6-phosphate synthase (TPS1) homologues from various species to complement the phenotypic defects of a Saccharomyces cerevisiae tps1 mutant, resulting in the classification of complementation into different groups based on metabolic patterns and fermentation capacity, shedding light on the role of TPS1 and trehalose-6-phosphate (T6P) as critical factors in sugar fermentation and glucose repression.
Accumulation of metabolic side products might favor the production of ethanol in Pho13 knockout strains
September 23, 2016
This article comments on work published by Collard et al. (Nat Chem Biol, 2016), which describes the discovery of a striking example illustrating the metabolite repair concept.