Exogenous addition of histidine reduces copper availability in the yeast Saccharomyces cerevisiae

July 6, 2014

The herein presented results indicate that in Saccharomyces cerevisiae, histidine cytotoxicity is associated with low copper availability inside cells, not with impaired copper uptake. Furthermore, it suggests that histidine cytotoxicity is involved in deficiency of mitochondrial copper.