Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
January 7, 2019
DNA recombination, repair and mutagenesis assays are powerful tools but each comes with its particular advantages and limitations. Here the most commonly used assays are reviewed, discussed, and presented as the guidelines for future studies.
Mutagenesis by host antimicrobial peptides: insights into microbial evolution during chronic infections
June 29, 2014
This article comments on work published by Limoli et al. ((PLoS Pathogens, 2014), which provides evidence that at subinhibitory levels, AMPs promote mutations in bacterial DNA, which enhance bacterial survival.
Where antibiotic resistance mutations meet quorum-sensing
June 25, 2014
This article comments on work published by Krašovec et al. (Nat Comm, 2014), which found that the modulation of de novo mutation to promote antibiotic resistance depends on the density of the bacterial population and cell-cell interactions (rather than, for instance, the level of stress).