Putative mitochondrial α-ketoglutarate-dependent dioxygenase Fmp12 controls utilization of proline as an energy source in Saccharomyces cerevisiae

September 19, 2016

The amino acid proline functions as a nitrogen source and as a stress protectant in the yeast Saccharomyces cerevisiae. However, utilization of proline as a carbon source in S. cerevisiae cells has not been studied yet. In this study, we discovered a novel proline metabolic pathway essentially mediated by the mitochondrial enzymes Put1, Put2, Alt1, KGDH, and TCA-cycle enzymes.