The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes

January 27, 2023

By CRISPR/Cas9 knockout and biophysical analysis, we show here that the invariant surface glycoprotein 75 directly binds the the century-old drug suramin and mediates uptake of additional naphthol-related compounds, making this glycoprotein a conduit for entry of at least one structural class of trypanocidal compounds.

An extensive endoplasmic reticulum-localised glycoprotein family in trypanosomatids

October 1, 2014

This work describes a novel family of type I membrane proteins ("invariant glycoproteins") and proposes them as trypanosomatid-specific ER-localised glycoproteins, with potential contributions to life cycle progression and immunity, that utilise oligomerisation as an ER retention mechanism.

What’s the role of autophagy in trypanosomes?

January 4, 2014

This article comments on Proto et al. (Microbial Cell, 2014), who report first insights into the molecular mechanism of autophagy in African trypanosomes by generating reporter bloodstream form cell lines.

Tracking autophagy during proliferation and differentiation of Trypanosoma brucei

December 26, 2013

This article provides insights into the function of autophagy, a cellular degradation and recycling pathway, in the protozoan parasite Trypanosoma brucei.