Following oxidative stress, cyclin C is relocalized from the nucleus to the outer membrane of the mitochondria where it interacts with the fission machinery and is required for stress-induced mitochondrial fission. The fluorescent images represent this relocalization in S. cerevisiae cells harboring YFP-cyclin C (green) and mitochondria-DsRed constructs before (upper left) and after (lower right) addition of 1mM H2O2. 100X magnification, deconvolved images of 0.2 µM slices at 0.2 µM spacing. Image acquired by Randy Strich and Katrina F. Cooper (Rowan University, USA). The cover is published under the Creative Commons Attribution (CC BY) license.