Ser/Thr protein phosphatases in fungi: structure, regulation and function
Authors:Joaquín Ariño1, Diego Velázquez1 and Antonio Casamayor1
doi: 10.15698/mic2019.05.677
Volume 6, pp. 217 to 256, published 24/04/2019.
1 Departament de Bioquímica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.
Keywords:
protein phosphorylation, protein phosphatases, cell signaling, S. cerevisiae, fungi.
Corresponding Author(s):
Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Joaquín Ariño, Diego Velázquez and Antonio Casamayor (2019). Ser/Thr protein phosphatases in fungi: structure, regulation and function. Microbial Cell 6(5): 217-256. doi: 10.15698/mic2019.05.677
© 2019 Ariño et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.
Abstract:
Reversible phospho-dephosphorylation of proteins is a major mechanism for the control of cellular functions. By large, Ser and Thr are the most frequently residues phosphorylated in eukaryotes. Removal of phosphate from these amino acids is catalyzed by a large family of well-conserved enzymes, collectively called Ser/Thr protein phosphatases. The activity of these enzymes has an enormous impact on cellular functioning. In this work we present the members of this family in S. cerevisiae and other fungal species, and review the most recent findings concerning their regulation and the roles they play in the most diverse aspects of cell biology.