Affiliations: 1 Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
2 Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
3 BioTechMed Graz, Graz, Austria.
4 Department of Biology, Université de Fribourg, Switzerland.
5 Institute for Research in Biomedicine; Barcelona, Spain
6 Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers , INSERM U 1138, Paris, France.
7 Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France.
8 8Université de Paris, Paris, France.
9 Sorbonne Université, Paris, France.
10 BioHealth Graz, Graz, Austria.
11 Central Lab Gracia, NAWI Graz, University of Graz, Graz, Austria.
12 Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany.
13 Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France.
14 Suzhou Institute for Systems Biology, Chinese Academy of Sciences, Suzhou, China.
15 Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden.
GATA, yeast, anti-aging, flavonoids, amino acids, autophagy.
O.K., G.K., D.C-G. and F.M. are the scientific co-founders of Samsara Therapeutics.
Andreas Zimmermann, Katharina Kainz, Sebastian Hofer, Maria A. Bauer, Sabrina Schroeder, Jörn Dengjel, Federico Pietrocola, Oliver Kepp, Christoph Ruckenstuhl, Tobias Eisenberg, Stephan J. Sigrist, Frank Madeo, Didac Carmona-Gutierrez and Guido Kroemer (2019). Targeting GATA transcription factors – a novel strategy for anti-aging interventions? Microbial Cell 6(5): 212-216. doi: 10.15698/mic2019.05.676
© 2019 Zimmermann et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.
Targeting GATA transcription factors – a novel strategy for anti-aging interventions?
Authors:Andreas Zimmermann1, Katharina Kainz1,2, Sebastian J. Hofer1,3, Maria A. Bauer1, Sabrina Schroeder1, Jörn Dengjel4, Federico Pietrocola5, Oliver Kepp6-9, Christoph Ruckenstuhl1, Tobias Eisenberg1,3,10,11, Stephan J. Sigrist12, Frank Madeo1,3,10, Guido Kroemer6-9, 13-15 and Didac Carmona-Gutierrez1
doi: 10.15698/mic2019.05.676
Volume 6, pp. 212 to 216, published 06/05/2019.
1 Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
2 Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
3 BioTechMed Graz, Graz, Austria.
4 Department of Biology, Université de Fribourg, Switzerland.
5 Institute for Research in Biomedicine; Barcelona, Spain
6 Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers , INSERM U 1138, Paris, France.
7 Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France.
8 8Université de Paris, Paris, France.
9 Sorbonne Université, Paris, France.
10 BioHealth Graz, Graz, Austria.
11 Central Lab Gracia, NAWI Graz, University of Graz, Graz, Austria.
12 Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany.
13 Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France.
14 Suzhou Institute for Systems Biology, Chinese Academy of Sciences, Suzhou, China.
15 Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden.
Keywords:
GATA, yeast, anti-aging, flavonoids, amino acids, autophagy.
Corresponding Author(s):
Conflict of interest statement:
O.K., G.K., D.C-G. and F.M. are the scientific co-founders of Samsara Therapeutics.
Please cite this article as:
Andreas Zimmermann, Katharina Kainz, Sebastian Hofer, Maria A. Bauer, Sabrina Schroeder, Jörn Dengjel, Federico Pietrocola, Oliver Kepp, Christoph Ruckenstuhl, Tobias Eisenberg, Stephan J. Sigrist, Frank Madeo, Didac Carmona-Gutierrez and Guido Kroemer (2019). Targeting GATA transcription factors – a novel strategy for anti-aging interventions? Microbial Cell 6(5): 212-216. doi: 10.15698/mic2019.05.676
© 2019 Zimmermann et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.
Abstract:
GATA transcription factors (TFs) constitute a conserved family of zinc-finger TFs that fulfill diverse functions across eukaryotes. Accumulating evidence suggests that GATA TFs also play a role in lifespan regulation. In a recent study, we identified a natural polyphenol, 4,4’-dimethoxychalcone (DMC), that extends lifespan depending on reduced activity of distinct GATA TFs. Prolonged lifespan by DMC treatment depends on autophagy, a protective cellular self-cleansing mechanism. In yeast, DMC reduces the activity of the GATA TF Gln3 and, genetic deletion of Gln3 is sufficient to increase autophagy levels during cellular aging. In addition, we observed similar changes in the abundance of several amino acids in the metabolome of DMC-treated and GATA/Gln3 depleted cells. Here, we examine current data on the involvement of GATA TFs in the regulation of autophagy and longevity in different organisms and explore if GATA TFs might be suitable targets for anti-aging interventions.