Affiliations: 1 AI Lab One, Wilhelmina van Pruisenweg 35, 2595 AN The Hague, The Netherlands.
Keywords:
aging, mitochondria, yeast, mPTP, cell death, adenine nucleotide translocator
Corresponding Author(s):
Damiano Pellegrino-Coppola, AI Lab One, Wilhelmina van Pruisenweg 35, 2595 AN The Hague, The Netherlands; damiano@ailab.one
Conflict of interest statement:
DPC is affiliated with AI Lab One.
Please cite this article as:
Damiano Pellegrino Coppola (2020). Regulation of the mitochondrial permeability transition pore and its effects on aging. Microbial Cell 7(9): 222-233. doi: 10.15698/mic2020.09.728
© 2020 Pellegrino Coppola. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and re-production in any medium, provided the original author and source are acknowledged.
Regulation of the mitochondrial permeability transition pore and its effects on aging
Authors:Damiano Pellegrino-Coppola1
doi: 10.15698/mic2020.09.728
Volume 7, pp. 222 to 233, published 22/06/2020.
1 AI Lab One, Wilhelmina van Pruisenweg 35, 2595 AN The Hague, The Netherlands.
Keywords:
aging, mitochondria, yeast, mPTP, cell death, adenine nucleotide translocator
Corresponding Author(s):
Conflict of interest statement:
DPC is affiliated with AI Lab One.
Please cite this article as:
Damiano Pellegrino Coppola (2020). Regulation of the mitochondrial permeability transition pore and its effects on aging. Microbial Cell 7(9): 222-233. doi: 10.15698/mic2020.09.728
© 2020 Pellegrino Coppola. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and re-production in any medium, provided the original author and source are acknowledged.
Abstract:
Aging is an evolutionarily conserved process and is tightly connected to mitochondria. To uncover the aging molecular mechanisms related to mitochondria, different organisms have been extensively used as model systems. Among these, the budding yeast Saccharomyces cerevisiae has been reported multiple times as a model of choice when studying cellular aging. In particular, yeast provides a quick and trustworthy system to identify shared aging genes and pathway patterns. In this viewpoint on aging and mitochondria, I will focus on the mitochondrial permeability transition pore (mPTP), which has been reported and proposed as a main player in cellular aging. I will make several parallelisms with yeast to highlight how this unicellular organism can be used as a guidance system to understand conserved cellular and molecular events in multicellular organisms such as humans. Overall, a thread connecting the preservation of mitochondrial functionality with the activity of the mPTP emerges in the regulation of cell survival and cell death, which in turn could potentially affect aging and aging-related diseases.