Biofilms by bacterial human pathogens: Clinical relevance – development, composition and regulation – therapeutical strategies

Affiliations:

¹ Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50, 8010 Graz, Austria.

² BioTechMed Graz, Austria.

³ Field of Excellence Biohealth – University of Graz, Graz, Austria.

^# A.S. and F.M. contributed equally to this work.

Keywords: 

biofilm-associated disease, nosocomial infections, Vibrio cholerae, Pseudomonas aeruginosa, staphylococci, treatment, biofilm.

Abbreviations:

AIP – autoinducing peptide;

CF – cystic fibrosis;

COPD – chronic obstructive pulmonary disease;

DGC – diguanylate cyclase;

eDNA – extracellular DNA;

EHEC – enterohemorrhagic E. coli;

EPS – extracellular polymeric substance;

GlcNAc – N-acetyl-D-glucosamine;

IBD – inflammatory bowel disease;

MRSA – methicillin-resistant S. aureus;

MSCRAMM – microbial surface components recognizing adhesive matrix molecule;

MSHA – mannose sensitive hemagglutinin;

PIA – polysaccharide intercellular adhesin;

PDE – phosphodiesterase;

QS – quorum sensing;

SERAM – secretable expanded repertoire adhesive molecule;

sRNA – small RNA;

UPEC – uropathogenic E. coli;

UTI -urinary tract infection;

UTR – untranslated region;

VPS – Vibrio exopolysaccharide.

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Conflict of interest statement:

The authors declare no conflict of interest.

Please cite this article as:

Adina Schulze, Fabian Mitterer, Joao P. Pombo and Stefan Schild (2021). Biofilms by bacterial human pathogens: Clinical relevance - development, composition and regulation - thera-peutical strategies. Microbial Cell 8(2): 28-56. doi: 10.15698/mic2021.02.741

© 2021 Schulze et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.