Affiliations: 1 Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark.
2 Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
3 The Center for Microbes, Development and Health (CMDH), Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Keywords:
(p)ppGpp, stringent response, nucleotide, amino acid, ribose 5’-phosphate.
Corresponding Author(s):
Yanjie Chao, The Center for Microbes, Development and Health (CMDH), Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China; yjchao@ips.ac.cn
Yong Everett Zhang, Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; yong.zhang@bio.ku.dk
Conflict of interest statement:
The authors have no conflict of interest to disclose.
Please cite this article as:
Paulina Katarzyna Grucela, Tobias Fuhrer, Uwe Sauer, Yanjie Chao and Yong Everett Zhang (2023). Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli? Microbial Cell 10(7): 141-144. doi: 10.15698/mic2023.07.799
© 2023 Grucela et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?
Authors:Paulina Katarzyna Grucela1, Tobias Fuhrer2, Uwe Sauer2, Yanjie Chao3 and Yong Everett Zhang1
doi: 10.15698/mic2023.07.799
Volume 10, pp. 141 to 144, published 01/06/2023.
1 Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark.
2 Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
3 The Center for Microbes, Development and Health (CMDH), Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Keywords:
(p)ppGpp, stringent response, nucleotide, amino acid, ribose 5’-phosphate.
Corresponding Author(s):
Conflict of interest statement:
The authors have no conflict of interest to disclose.
Please cite this article as:
Paulina Katarzyna Grucela, Tobias Fuhrer, Uwe Sauer, Yanjie Chao and Yong Everett Zhang (2023). Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli? Microbial Cell 10(7): 141-144. doi: 10.15698/mic2023.07.799
© 2023 Grucela et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
The bacterial stringent response and its effector alarmone guanosine penta- or tetra – phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (virulence). (p)ppGpp does so by binding to its numerous target proteins and reprograming bacterial transcriptome to tune down the synthesis of nucleotides and rRNA/tRNA, and up-regulate amino acid biosynthesis genes. Recent identification of more novel (p)ppGpp direct binding proteins in Escherichia coli and their deep studies have unveiled unprecedented details of how (p)ppGpp coordinates the nucleotide and amino acid metabolic pathways upon stringent response; however, the mechanistic link between nucleotide and amino acid metabolisms remains still incompletely understood. Here we propose the metabolite ribose 5’-phosphate as the key link between nucleotide and amino acid metabolisms and a working model integrating both the transcriptional and metabolic effects of (p)ppGpp on E. coli physiological adaptation during the stringent response.