Phospholipases A and Lysophospholipases in protozoan parasites
Authors:Perrine Hervé1, Sarah Monic1, Frédéric Bringaud1 and Loïc Rivière1
doi: 10.15698/mic2023.10.805
Volume 10, pp. 204 to 216, published 02/10/2023.
1 Université de Bordeaux, Microbiologie Fondamentale et Pathogénicité, CNRS UMR 5234, Bordeaux, France.
Keywords:
phospholipases, lysophospholipases, protozoan, host-pathogen interactions, virulence factors, metabolism.
Corresponding Author(s):
Conflict of interest statement:
The authors declare no competing interests.
Please cite this article as:
Perrine Hervé, Sarah Monic, Frédéric Bringaud and Loïc Rivière (2023). Phospholipases A and Lysophospholipases in protozoan parasites. Microbial Cell 10(10): 204-216. doi: 10.15698/mic2023.10.805
© 2023 Hervé et al.. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Phospholipases (PLs) and Lysophospholipases (LysoPLs) are a diverse group of esterases responsible for phos-pholipid or lysophospholipid hydrolysis. They are involved in several biological processes, including lipid catabolism, modulation of the immune response and membrane maintenance. PLs are classified depending on their site of hydrolysis as PLA1, PLA2, PLC and PLD. In many pathogenic microorganisms, from bacteria to fungi, PLAs and LysoPLs have been described as critical virulence and/or pathogenicity factors. In protozoan parasites, a group containing major human and animal pathogens, growing literature show that PLAs and LysoPLs are also involved in the host infection. Their ubiquitous presence and role in host-pathogen interactions make them particularly interesting to study. In this review, we summarize the literature on PLAs and LysoPLs in several protozoan parasites of medical relevance, and discuss the growing interest for them as potential drug and vaccine targets.