The metabolites of lactic acid bacteria: classification, biosynthesis and modulation of gut microbiota
Authors:Huang Tang1,2, Wanqiu Huang1,2 and Yu-Feng Yao1,2,3,4,5
doi: 10.15698/mic2023.03.792
Volume 10, pp. 49 to 62, published 08/02/2023.
1 Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
2 Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
3 Department of Infectious Diseases, Shanghai Ruijin Hospital, Shanghai 200025, China.
4 State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
5 Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases (20dz2261100), Shanghai 200025, China.
Keywords:
metabolites, lactic acid bacteria, gut microbiota, immune system.
Corresponding Author(s):
Conflict of interest statement:
The authors have declared no conflict of interest.
Please cite this article as:
Huang Tang, Wanqiu Huang and Yu-Feng Yao (2023). The metabolites of lactic acid bacteria:classification, biosynthesis and modulation of gut microbiota. Microbial Cell 10(3): 49-62. doi: 10.15698/mic2023.03.792
© 2023 Tang et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Lactic acid bacteria (LAB) are ubiquitous microorganisms that can colonize the intestine and participate in the physiological metabolism of the host. LAB can produce a variety of metabolites, including organic acids, bacteriocin, amino acids, exopolysaccharides and vitamins. These metabolites are the basis of LAB function and have a profound impact on host health. The intestine is colonized by a large number of gut microorganisms with high species diversity. Metabolites of LAB can keep the balance and stability of gut microbiota through aiding in the maintenance of the intestinal epithelial barrier, resisting to pathogens and regulating immune responses, which further influence the nutrition, metabolism and behavior of the host. In this review, we summarize the metabolites of LAB and their influence on the intestine. We also discuss the underlying regulatory mechanisms and emphasize the link between LAB and the human gut from the perspective of health promotion.