FIGURE 2: Intrinsic and antibiotic induced implications of bacterial efflux pumps. Bacterial efflux pumps function by (1) increasing bacterial pathogenicity by extruding antibacterial molecules produced from the host and secreting bacterial virulence factor, (2) reducing antibiotic efficacy by pumping them out of the bacteria, thus lowering intracellular concentration of antibiotics, which can increase development of further resistance.