Autophagy: machinery and regulation
Authors:Zhangyuan Yin, Clarence Pascual and Daniel J. Klionsky
Life Sciences Institute, and Department of Molecular, Cellular and Developmental Biology; University of Michigan, Ann Arbor, MI, USA 48109.
Keywords:
autophagy, autophagosome formation, physiological roles, cellular homeostasis, pathogenesis, physiological roles, regulation.
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Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Zhangyuan Yin, Clarence Pascual and Daniel J. Klionsky (2016). Autophagy: machinery and regulation. Microbial Cell 3(12): 588-596. doi: 10.15698/mic2016.12.546
© 2016 Yin et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Macroautophagy/autophagy is an evolutionarily conserved cellular degradation process that targets cytoplasmic materials including cytosol, macromolecules and unwanted organelles. The discovery and analysis of autophagy-related (Atg) proteins have unveiled much of the machinery of autophagosome formation. Although initially autophagy was regarded as a survival response to stress, recent studies have revealed its significance in cellular and organismal homeostasis, development and immunity. Autophagic dysfunction and dysregulation are implicated in various diseases. In this review, we briefly summarize the physiological roles, molecular mechanism, regulatory network, and pathophysiological roles of autophagy.
doi: 10.15698/mic2016.12.546
Volume 3, pp. 588 to 596, published 01/12/2016.