Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella enterica
Authors:Kristy L. Hentchel1,2 and Jorge C. Escalante-Semerena1
doi: 10.15698/mic2015.11.239
Volume 2, pp. 451 to 453, published 12/10/2015.
1 Department of Microbiology, University of Georgia, Athens, GA 30602, USA.
2 Current address: Department of Biochemistry & Molecular Biology, University of Chicago, Chicago, IL 60637, USA.
Keywords:
sirtuin deacetylase (CobB), protein acetyltransferase (Pat), reversible lysine acetylation (RLA), transcriptional regulation, IolR, myo-inositol utilization, Salmonella
Corresponding Author(s):
Conflict of interest statement:
The authors have no conflict of interest to declare.
Please cite this article as:
Kristy L. Hentchel and Jorge C. Escalante-Semerena (2015). Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella enterica. Microbial Cell2(11): 451-453.
© 2015 Hentchel and Escalante-Semerena. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
The extensive involvement of the reversible lysine acylation (RLA) system in metabolism has attracted the attention of investigators interested in understanding the fundamentals of prokaryotic and eukaryotic cell function. Research in this area of cell physiology is diverse, ranging, among others, from probing the molecular bases of human diseases, to optimizing engineered metabolic pathways for biotechnological applications, to advancing our understanding of fundamental cellular processes. A gap of knowledge exists in our understanding of the regulatory circuitry that integrates the expression of genes encoding modifiers (i.e., acyltransferases) and demodifiers (i.e., deacylases) with the expression of genes encoding known targets of the system. Here we discuss the implications of recently reported work performed in the enteropathogen Salmonella enterica (mBio (2015) 6(4):e00891-15), which provided the first insights into the integration of the transcriptional regulation of genes encoding the RLA system with the acs gene encoding the central metabolic enzyme acetyl-CoA synthetase (Acs).